Articular cartilage proteoglycans in osteoarthritic STR/Ort mice

Chondrocyte multiplication in osteoarthritic articular cartilage.

Differential Immunohistochemical Expression Pattern of Galectin-3 in Normal and Osteoarthritic Human Articular Cartilage

Background: Previous studies have shown that Galectin-3, a member of lectin family, is expressed in developing cartilage in mouse embryo and also in growth plate of long bones.   Objective: In the present work, the expression pattern of Galectin-3 in normal and various grades of osteoarthritic (OA) human articular cartilage has been studied.   Methods: Using immunohistochemistry and standard we...

The heterogeneity of cartilage proteoglycans. Isolation of different types of proteoglycans from bovine articular cartilage.

Proteoglycans, proteins, and glycoproteins were extracted from femoral condyle (FC) and metacarpalphalangeal (MP) articular cartilages and fractionated by sequential density gradient sedimentation under dissociative conditions. The major high density proteoglycan (PG-I) accounted for 74% of the total proteoglycan extracted from the MP cartilage and 79% of that from the femoral condyle. These pr...

Ultrastructure of chondrocytes in osteoarthritic femoral articular cartilage.

BACKGROUND Osteoarthritis (OA) is a common problem in elderly, but it is not an inevitable feature of ageing. About 80-90% of individuals of both sexes have radiographic evidence of OA by the time they reach an age of 65. But not all of them have the symptoms like pain and decreased joint motion. OBJECTIVE The objective of the present study was conducted to find out whether the osteoarthritic...

Expression of osteonectin in articular cartilage of osteoarthritic knees.

The expression of osteonectin (ON) in osteoarthritic articular cartilage was investigated by enzyme immunohistochemistry and colloidal gold immunoelectron microscopy. A total of 96 specimens from 9 knees of 8 patients with osteoarthritis (OA) were examined. In OA cartilage, ON-positive cells varied in distribution and were not seen in all the specimens obtained from the same patient. However, i...